Pharmacokinetic interactions, ADRs

Nutritional factors are also responsible for ADRs. These factors include the interaction of drugs and nutrients, and altered pharmacokinetics related to nutritional status. 

SAEs), and unexpected ADRs. A common practice in the first phase I clinical trial is to collect blood and urine specimens to obtain preliminary pharmacokinetic information in humans. Additional phase I clinical trials are frequently conducted later to address specific concerns such as relative bioavailability comparison when the formulation is changed effect of food and time of feeding potential for drug-drug interactions pharmacokinetics in subpopulations such as... 

It has been estimated that 6.9% of ADRs are due to drug-drug interactions (6). The most likely reason for an adverse drug interaction is the pharmacokinetic changes that result in altered metabolism or excretion of drugs, or the... 

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