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Pharmacokinetic Characteristics of mAbs

Compared to small-molecule dmgs, therapeutic mAbs display different pharmacokinetic characteristics, including nonlinear pharmacokinetic behavior. As the majority of therapeutic mAbs present IgG (or more specially IgGl) molecules, the emphasis will be placed on this isotype, although the characteristics of newer types of molecule such as antibody fragments will also be included. [Pg.68]

Before discussing the pharmacokinetic characteristics of therapeutic mAbs, the present section will focus on the catabolism of physiological antibodies. This process is also highly relevant for therapeutic mAbs. [Pg.65]

Well-known macromolecules that have been approved and are currently marketed are listed in Table 32.1. This chapter presents information on mABs currently marketed or under investigation and discusses methodology used to assay macromoleculeS/ interspecies scaling of macromoleculeS/ pharmacokinetic (PK) characteristics of macromoleculeS/ and pharmacodynamics (PD) of macromolecules. [Pg.479]

See other pages where Pharmacokinetic Characteristics of mAbs is mentioned: [Pg.46]    [Pg.68]    [Pg.69]    [Pg.71]    [Pg.73]    [Pg.75]    [Pg.77]    [Pg.46]    [Pg.68]    [Pg.69]    [Pg.71]    [Pg.73]    [Pg.75]    [Pg.77]    [Pg.78]    [Pg.85]    [Pg.513]    [Pg.1150]   


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MAb

Pharmacokinetic characteristics

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