Pharmacodynamics receptor theory

Elizabetli, C.M., Della, P., Oscar Ploeger, B.A. and Voskuyl, R.A. (2007) Mechanism-based pharmacokinetic-pharmacodynamic modeling hiophase distribution, receptor theory, and dynamical systems analysis. Annual Review of Pharmacology and Toxicology, 47, 357-400. 

Danhof, M., de Jongh, J., De Lange, E. C., Della Pasqua, O., Ploeger, B. A., Voskuyl, R. A. Mechanism-based pharmacokinetic-pharmacodynamic modeling biophase distribution, receptor theory, and dynamical systems analysis. Anna Rev Pharmacol Toxicol 2007,47 357-400. 

Iliadis, A. and Cano, J., A new pharmacodynamic modelling approach based on receptors theory, 3th European Congress of Biopharmaceutics and Pharmacokinetics, edited by J. Aiache and J. Hirtz, Vol. 3, Imprimerie de l Universite, Clermont-Ferrand, Freiburg, 1987, pp. 65-74. 

Danhof, M. et al., Mechanism-based pharmacokinetic-pharmacodynamic modeling Biophase distribution, receptor theory, and dynamical systems analysis. Annu. Rev. 

Pharmacodynamics describes the time course and the magnitude of pharmacological response of drugs. Based on the classic receptor-occupancy theory, after drug molecules reach the target biophase, it binds to the receptors to form the drug-receptor complex to exert pharmacological response (Fig. 2). 

The choice of model should be based on biological, physiological, and pharmacokinetic plausibility. For example, compartmental models may be used because of their basis in theory and plausibility. It is easy to conceptualize that a drug that distributes more slowly into poorly perfused tissues than rapidly perfused tissues will show multi-phasic concentration-time profiles. Alternatively, the Emax equation, one of the most commonly used equations in pharmacodynamic modeling, can be developed based on mass balance principles and receptor binding kinetics. 

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