Pharmacodynamics drug interactions

Davis MP, Walsh D Methadone for relief of cancer pain A review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. Support Care Cancer 2001 9 73. [PMID 11305074]... 

Williams D, Feely J. Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clin Pharmacokinet 2002 41(5) 343-70. 

J.R.B.J. Brouwers, and P.A.G.M. de Smet, Pharmacokinetic-pharmacodynamic drug interactions with nonsteroidal anti-inflammatory drugs. Clin. Pharmacokinet. 27 462-485, 1994. 

The seizures occurred in the presence of high concentrations of clomipramine in this case, suggesting a pharmacodynamic drug interaction, since neither agent given alone provoked seizure activity, whereas the combination did. It is, however, possible that clomipramine might have caused a rise in olanzapine blood concentrations, which were not measured. 

SSRIs can also cause pharmacodynamic drug interactions for some time after withdrawal, through residual serotonin reuptake blocking activity. 

A pharmacodynamic drug interaction could not be excluded when a 60-year-old man developed delirium at a serum lithium concentration of 0.97 mmol/1 when taking lithium and haloperidol (158). 

Grossberg GT, Stahelin HB, Messina JC, Anand R, Veach J. Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications. Int J Geriatr Psychiatry 2000 15(3) 242-7. 

TABLE 70-9 Pharmacodynamic Drug Interactions Involving Tricyclic Antidepressants... 

Ragueneau I, Poirier JM, Radembino N, Sao AB, Funck-Brentano C, Jaillon P. Pharmacokinetic and pharmacodynamic drug interactions between digoxin and macrogol 4000, a laxative polymer, in healthy volunteers. Br J Clin Pharmacol 1999 48(3) 453-6. 

Table 3 Pharmacodynamic drug interactions with NSAIDs ...

Pharmacokinetic drug interactions occur where one drug affects the absorption, distribution, metabolism or excretion of the other. Pharmacokinetic drug interactions are harder to predict than pharmacodynamic drug interactions and in many cases, affect different patients differently. 

Vourvahis, M. and Kashuba, A. D. (2007) Mechanisms of pharmacokinetic and pharmacodynamic drug interactions associated with ritonavir-enhanced tipranavir. Pharmacotherapy 27, 888-909. 

Give several examples of warfarin s role in pharmacokinetic and pharmacodynamic drug interactions. 

---