Pharmaceutical interest, compounds

This reaction has been applied to the synthesis of a variety of pharmaceutically interesting compounds. 

This chapter describes an area of research that is finding new uses every day. The tools of computational chemistry—computers and software—have become so ubiquitous that there are few chemists left today who have not heard of them or used them. However, the reader may reasonably ask Why is there a chapter on computational chemistry in a book on stress testing of pharmaceutically interesting compounds The reason does not lie in a vast number of papers crying for review. Indeed, relatively little work has been published in this area thus far. So what is the reason The objective of this chapter is to increase awareness of how computational chemistry can be used by pharmaceutical chemists to help confront some of the research problems they face in stress testing research. Hence, the nature of this chapter is intended to be primarily tutorial... and perhaps with a little proselytizing for increased use of the powerful techniques of computational chemistry now available. 

To synthesize these pharmaceutically interesting compounds, metha-nolic solutions of acetic acid 6 (2.0 eq.)/2-formylbenzoic acid 7 (1.0 eq.) and aniline 8 (2.0 eq.)/potassium cyanide 9 (1.2 eq.) were introduced into the reactor from separate inlets, thus ensuring the formation of HCN and the... 

As a result of the numerous possibilities for modification at both the nitrogen and the silicon centers, this class of (aminomethyl)silanes has considerable potential for use in synthesis of pharmaceutically interesting compounds [11]. The metalated species can be used as reagents for the transfer of stereogenic centers [la] as well as building blocks for novel ligands of organometallic systems [12]. 

Scheme 4.84 Asymmetric hydroformylation of allyl cyanide and subsequent steps to a building block with the potential for the construction of pharmaceutically interesting compounds.

Corey-Fuchs reaction has also been employed to make pharmaceutically interesting compounds. The treatment of bromo-acetylene 20 with /-BuLi and the quench of resulting lithium alkylanide with phenyl isocyanate produced amide 21. After SEM removal, NMDA receptor antagonist 22 for stoke therapy was obtained. ... 

This article examines what is commonly called computer-aided drug design (CADD). This is the largest and most well established area of computer-aided (or -assisted) molecular design (CAMD). " Many of the concepts and methodologies that apply to design of pharmaceutically interesting compounds also apply to other compounds and materials of scientific or commercial interest. 

The reactivity of the enolsUane has provided opportunities for a stepwise reaction that culminates in cycloaddition even prior to the formation of sUoxyallyl cations, allowing the unprecedented communication of chirality from the enolsilane derivative to the cycloaddition. Future exploitations and applications of these reactions to the synthesis of natural products and pharmaceutically interesting compounds are anticipated. 

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