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Pharmaceutical industry benzodiazepines

This chapter concerns synthesis. How is combinatorial chemistry pertinent to this discussion Many small molecules can be synthesized using combinatorial techniques and evaluated for biological activity. One example is the synthesis of substituted benzodiazepines, such as 290, shown in Scheme 10.26.296 This approach has become very important in the pharmaceutical industry for drug discovery.207... [Pg.901]

This chemical intermediate from the synthesis of benzodiazepines produced contact allergic reactions in three pharmaceutical industry workers between 1962 and 1978 (Kleine-Natrop and Richter 1980). [Pg.1047]

Due to their importance to the pharmaceuticals industry, there are already many known routes to benzodiazepines. Their preparation from readily available isatins has now been described treatment of the chloroacetyl derivatives with hexamine gives the product (Scheme 103). Some 3-benzazepines (e.g. 225) have... [Pg.252]

Until 1992, combinatorial libraries were almost entirely restricted to peptides and oligonucleotides, but peptides are not ideal as drugs because they have poor oral bioavail-ablity and a short half-life, so the pharmaceutical industry needed more useful libraries. Chiron experimented with N-substituted glycine peptoids (Figure 2), where the side chains are attached to the amide nitrogen,but the real breakthrough in what is usually called small-molecule chemistry came when Bunin and Ellman reported the solid-phase synthesis of a 1,4-benzodiazepine library (Figure 3). Very soon afterwards DeWitt et al. reported a similar synthesis of benzodiazepines... [Pg.409]


See other pages where Pharmaceutical industry benzodiazepines is mentioned: [Pg.16]    [Pg.39]    [Pg.473]    [Pg.134]    [Pg.135]    [Pg.214]    [Pg.224]    [Pg.53]    [Pg.212]    [Pg.27]    [Pg.82]    [Pg.549]    [Pg.363]    [Pg.382]    [Pg.3]    [Pg.336]   
See also in sourсe #XX -- [ Pg.255 ]




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Pharmaceutical industry

Pharmaceuticals benzodiazepines

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