Phagocytes, bactericidal action

Chemiluminescence of Phagocytic Cells, The bactericidal action of phagocytic cells such as the polymorphonuclear leukocytes (PMN) was shown by Klebanoff (1967 1968) to result from the reaction of the enzyme myeloperoxidase MPO and H2O2 in the presence of halide ions. The reactions postulated were... 

In addition to helping organisms adhere to surfaces (e.g. Streptococcus mutans and teeth) and protecting them from body defence mechanisms, such as the bactericidal action of serum or ingestion and killing by phagocytes (e.g. the pneumococci and Staphylococcus aureus) capsules probably protect cells from desiccation in natural environments which are prone to periodic drying. Their survival value to the cells therefore justifies the metabolic effort required for their production. 

Clofazimine is a weakly bactericidal dye that has some activity against M. leprae. Its precise mechanism of action is unknown but may involve mycobacterial DNA binding. Its oral absorption is quite variable, with 9 to 70% of the drug eliminated in the feces. Clofazimine achieves significant concentrations in tissues, including the phagocytic cells it has a plasma half-life of 70 days. It is primarily excreted in bile, with less than 1% excretion in urine. 

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