Phagocyte NADPH-oxidase Phox

Huang, J., and Kleinberg, M. E. (1999). Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox)./. Biol. Chem. 274, 19731-19737. 

Figure 12 CGD mice lack the gp91 phox subunit of NADPH oxidase, (a) Immunohis-tochemistry (above) and immunoblotting (below, note the lower molecular weight is common in mice) experiments show that CGD mice lack the gp91 phox subunit of the en2yme, compared to wild mice (darker stain). Expression of p22 phox is similar in the CGD versus the wild mice. Note that in the CGD mice, the subunit is absent from the PA and alveolar (A) epithelial cells as well as from phagocytes (arrows). (From Ref. 99.)...

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