Phago-lysosomes

In the case of SMANCS, it is essentially taken up into the cell by endocytosis, and acidic pH (<6) of phago-lysosome liberates the active component (NCS) by spontaneous hydrolysis of the maleylamide bond. Then chromophore of NCS diffuses into the cytoplasm or to the nucleus, where the drug action to DNA would occur [70, 71]. Another acid-labile bond is azide bond which is discussed by other researchers [80]. 

Meagher J, Zellweger R, Filgueira L (2005) Functional dissociation of the basolateral transcytotic compartment from the apical phago-lysosomal compartment in human osteoclasts. J Histochem Cytochem 53 665-670... 

Lysosomes are in effect a cellular waste-bin, and play an important role in the turnover and degradation of cytoplasmic organelles and phago-cytosed particles. They facilitate receptor-mediated endocytosis of many macromolecules from the cell membrane. Lysosomes carry hydrolases that degrade nucleotides, proteins, lipids and phospholipids they also remove carbohydrate, sulphate, or phosphate groups from molecules. Lysosomes store iron, either as soluble ferritin or as products of ferritin degradation, such as haemosiderin. Abnormalities associated with lysosomal function cause a variety of storage disorders such as Tay-Sachs disease [9]. 

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