Pethidine Phenobarbital

Cj H7N 140-29-4) see Azatadine Dicycloverine Disopyramide Ethoheptazine Isoaminile Levocabastine Mephenytoin Methylphenidate Methylphenobarbital Milnacipran hydrochloride Oxeladin Pentapiperide Pentoxyverine Pethidine Phenglutarimide Pheniramine Phenobarbital Tolazoline Triamterene Valethamate bromide 1 -benzy l-4-cyanopiperidine (C]3H 9N2 62778-37-4) see Ketanserin... 

Forced diuresis by furosemide, mannitol etc. and altering the urinary pH- increasing the pH of urine favours ionisation of acidic drugs like salicylates, phenobarbital etc. whereas reducing the pH favours ionisation of basic drugs like pethidine, amphetamine etc. 

Two main effects occur here. First, change in the pH of urine—weak bases, such as pethidine, are more easily excreted in an acid urine while alkalinisation promotes excretion of weak acids, such as salicylates and phenobarbital. Second, drugs that compete for an active excretion mechanism will reduce each other s elimination—probenecid was used in the early days of penicillin to conserve the drug, while less desirable interactions also occur, e.g. chlorpropamide and phenylbutazone interact to give increased levels of chlorpropamide and a danger of hypoglycaemia. 

Pethidine see Meperidine Peyote see Mescaline Phendimetrazine see Diet pills Phenelzine see Antidepressants Phenobarbital see Barbiturates Phentermine see Diet pills... 

OPIOIDS ANTIEPILEPTICS 1. Barbiturates T sedative effects of opioids 2.1 efficacy of fentanyl and methadone with carbamazepine, phenobarbital, phenytoin or primidone 3. Carbamazepine l tramadol levels 4. Risk of pethidine toxicity 1. Additive sedative effect 2. t hepatic metabolism of fentanyl and methadone, and possibly an effect at the opioid receptor 3. Carbamazepine T metabolism of tramadol 4. Phenytoin induces metabolism of pethidine, which causes T level of a neurotoxic metabolite 1. Monitor respiratoiy rate and conscious levels 2. Be aware that the dose of fentanyl and methadone may need to be t 3. Watch for poor effect of tramadol. Consider using an alternative opioid 4. Co administer with caution the effect may be i by administering pethidine intravenously... 

Studies suggest that phenobarbital stimulates the liver enzymes concerned with the metabolism (A/-demethylation) of pethidine so that the production of its more toxic metabolite (norpethidine) is increased. The toxicity seen appears to be the combined effects of this compound and the directly sedative effects of the barbiturate. "... 

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