Pesticides dieldrin

A chromatographic analysis for the chlorinated pesticide Dieldrin gives a peak with a retention time of 8.68 min and a baseline width of 0.29 min. How many theoretical plates are involved in this separation Given that the column used in this analysis is 2.0 meters long, what is the height of a theoretical plate ... 

In cultured rat glial cells, ChK prevented the inhibition of gap junction-mediated intercellular communication by two organochlorine pesticides, dieldrin and endosulfan.29 In these experiments, pretreatment of glial cells with 1 or 10 pM ChK prevented, in a dose-dependent manner, dieldrin- or endosulfan-induced inhibition of gap junction-mediated communication, assayed by fluorescent dye... 

Richardson JR, Caudle WM, Wang M, et al. Developmental exposure to the pesticide dieldrin alters the dopamine system and increases the neurotoxicity in an animal model of Parkinson s disease. TASPB J 2006 20 1695 97. 

An initial report (Arnold et al. 1996) that binary mixtures of hydroxylated PCBs and weakly estrogenic pesticides (dieldrin, endosulfan, toxaphene, and chlordane) resulted in synergistic increases in estrogen receptor binding and reporter gene-expression in transfection-facilitated yeast and endometrial... 

TABLE 3.6. The Dose-Response Characteristics of Liver Tumor Enhancement in CF-1 Mice by the Nongenotoxic Pesticide Dieldrin... 

Polycyclic hydrocarbons, pesticides (dieldrin, ODD, DDT) and sulpha drugs were investigated. No detection limits and sensitivities were stated. 

The cyclodiene pesticides, dieldrin and endrin, are degraded by microorganisms. Many of the isolates tested were obtained from soils that had been treated with dieldrin. Generally, this work was carried out aerobically, but the cultures were not aerated. Some facultative anaerobes may have similar reactions under oxygen-deflcient and anaerobic conditions. One study included organisms that are anaerobic in... 

An example of the calculation of a final acute/chronic ratio is shown in Table V for the pesticide dieldrin. Chronic values for this pesticide were available for only four species in 1980 when the guidelines for dieldrin were established (EPA, 1980a), and therefore it was necessary to use acute/chronic ratios to estabhsh the final chronic value. Acute toxicity values were available in only three of the four cases where chronic effects were studied, but the three species satisfied the criteria for calculating acute/chronic ratios in both freshwater and salt water. Since the acute/chronic ratios for the three species differed by less than a factor of 2, it was appropriate to calculate the final acute/chronic ratio for dieldrin by taking the geometric mean of the three ratios, which is [(11)(9.1)(6.2)] / = 8.5. Final acute values for dieldrin in freshwater (EPA, 1996b) and salt water are 0.48 and 0.71 ppb, respectively. Hence the final chronic values for dieldrininfreshwaterand saltwater areO.48/8.5 = 0.056 ppb and 0.71/8.5 = 0.084 ppb, respectively. 

Q 4. An adduct I is formed by the Diels—Alder reaction of cyclopentadiene with ethyne. When I is treated with hexachlorocyclopentadiene (II), it forms the well-known pesticide, Aldrin (HI). Epoxidation of III with peracid produces another pesticide, Dieldrin (IV)- Draw strucmres of I, II, III, and IV and explain how these products are formed. 

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