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Pesticide poisoning oxime/atropine

Kusic et al. (1991) have tested the oxime HI-6 in OP pesticide poisoning in 60 patients. HI-6 was administered four times a day as a single i.m. injection of 500 mg with atropine and diazepam treatment. Oxime therapy was started on admission and continued for 2 to 7 days. Most patients were treated with HI-6 and nine patients severely poisoned with quinalphos were treated 2-PAM Cl (1,000 mg four times per day). HI-6 rapidly reactivated human red blood cell AChE inhibited by diethoxy OPs (phorate, pyr-idaphenthion, quinalphos) as well as that inhibited by dichlorvos (a dimethoxy OP). AChE inhibited with other dimethoxy OPs (dimethoate and phosphamidon) was reported to be resistant to HI-6 treatment, whereas reactivation with malathion was slow (reactivation half-time 10 h). Both HI-6 and 2-PAM successfully reactivated AChE in quinalphos-poisoned patients, with HI-6 acting as a faster AChE reactivator than 2-PAM. [Pg.992]

Oximes Oximes are compounds capable of reactivating, in some cases the complex formed by the OP compounds and acetylcholinesterase. Chemically, oximes are mono or bispyridinium compounds which can bind to the OP-AChE complex and cause the nerve agent molecule to separate from the enzyme. Importantly, oximes can reverse the actions of OP at both muscarinic and nicotinic receptors. Thus, unlike atropine, they act at the neuromuscular junction and can thus reduce the degree of paralysis. They have been shown to be effective in the management of OP pesticide poisoning. However, their effectiveness against nerve... [Pg.150]


See other pages where Pesticide poisoning oxime/atropine is mentioned: [Pg.723]    [Pg.157]    [Pg.333]    [Pg.718]    [Pg.723]    [Pg.65]    [Pg.210]    [Pg.877]    [Pg.985]    [Pg.75]    [Pg.335]    [Pg.403]    [Pg.967]    [Pg.1057]    [Pg.1065]   
See also in sourсe #XX -- [ Pg.722 , Pg.723 , Pg.724 ]




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Pesticide poisoning oximes

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