Perspiratio insensibilis

Although SC water is relentlessly lost to the environment by perspiratio insensibilis (about 2-8 ml/mVh at rest) (Forslind 1994 Rudikoff 1998), an almost constant amount of water is retained both inside the protein-rich keratinocytes (20%) and in the intercellular space (10%) (Imokawa et al. 1991). A highly specialized and dynamic permeability skin barrier controls the movement of water across the SC as well as the penetration of environmental chemical, physical and biological hazards (Kerscher et al. 1991 Cork 1997), allowing the body to suffer little change while encountering the different environments that are a part of daily life (Spencer 1988). 

---