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Perspectives of Renal Delivery with Alkylglycoside Vectors

7 Perspectives of Renal Delivery with Alkylglycoside Vectors [Pg.131]

Concentration as a result of uptake and subsequent retention of the hgand in the proximal tubules may be suitable for certain types of therapeutic agents. The plasma concentration of Glc-S-C8-NBD fell rapidly while the kidney concentration of the intact ligand remained almost constant, the kidney-to-plasma concentration ratio being 200 at 30 min after injection [Pg.131]

5 Delivery of Drugs and Antisense Oligonunucleotides to the Proximal Tubular Cell [Pg.132]




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