Peroxidase-mediated oxidation

Oubrahim, H., Richard, J.M., Cantin-Esnault, D. (1998). Peroxidase-mediated oxidation, a possible pathway for activation of the fungal nephrotoxin orellanine and related compounds. ESR and spin-trapping studies, Free Radic. Res., 28, 497-505. 

Tab. 31. Horseradish peroxidase-mediated oxidative dimerization of substituted tyrosine derivatives.

Enzymatically Peroxidase mediated oxidation Chemically Oxidation by hydrogen peroxide (3-6%)... 

Huang Q, Weber WJ (2005) Transformation and removal of bisphenol A from aqueous phase via peroxidase-mediated oxidative coupling reactions efficacy, products, and pathways. Environ Sci Technol 39 6029-6036... 

Likewise, when the product of the peroxidase-mediated oxidation is a cation radical, R [Eqs. (5,6)], Eq. (17) may be written ... 

Class in plant peroxidases, such as that purified from strawberries, are able to oxidize (+)-catechin with ki values of 0.57 pM s at pH 5.0 [36]. The peroxidase-mediated oxidation of (+)-catechin leads to the formation of dimers such as dehydrodicatechin A and B4, trimers, tetramers and oligomers of different degrees of polymerization [146,147],... 

McCormick, M.L., G.R. Buettner, and B.E. Britigan The spin trap alpha-(4-pyridyl-l-oxide)-A-tcrt-butyl-nitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents J. Biol. Chem. 270 (1995) 29265-29269. 

Penketh, P.G. et al.. Inhibition of DNA cross-hnking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone, J. Biol. Chem., 276, 34445,2001. 

Application of semiempirical molecular orbital techniques to the study of peroxidase-mediated oxidation of phenols, anilines, sulphides and thiobenzamides. Tetrahedron. Al 7525 (1991)... 

In some cases, quinone-imine formation requires an initial hydroxylation step as illustrated with the nonsteroidal anti-inflammatory drug and idiosyncratic hepatotoxin diclofenac. Thus, CYP-catalyzed aromatic hydroxylation para to the aniline nitrogen affords thepara-hydroxydiclofenac isomers, which can then undergo CYP or peroxidase-mediated oxidation to the quinone-imines amenable to trapping with GSH (Scheme 6) (Tang et al., 1999 Miyamoto et al., 1997). The aniline nitrogen in quinone-imine derivatives can also be part of a heterocyclic... 

Recent studies by Nielsen et al. (23) have shown that simultaneous addition of hypoxantiiine and catalase to raw milk preserves ascorbate considerably. This indicates that the formed radical species induced by hydrogen peroxide and milk peroxidases are inq)ortant for die loss of ascorbate in addition to tiie direct oxidation of ascorbate through reaction widi superoxide. This is supported by the fact that addition of hydrogen peroxide to raw milk initiates a dramatic decrease in tile ascorbate content (23). This enzymatically catalyzed pathway is supported by the fiuit that addition of hydrogen peroxide to UHT-milk only results in a minor oxidation of ascorbate vhich in cates tiiat Fenton reaction chemistry is only of minor in rtance. Overall, tiie present data states that xaiiuiine oxidase-and peroxidase-mediated oxidation are crucial tiictors in ascorbate oxidation as suggested by (33). 

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