Permeability Measurements High-phospholipid in Surfactant-free Solutions

Permeability Measurements High-phospholipid in Surfactant-free Solutions 

Most of the permeabilities of the bases decrease steadily as the phospholipid fraction increases, though there are some significant exceptions. Metoprolol, which is moderately permeable in the DOPC lipid, becomes a top performer in 10% egg lecithin, though at the 68% soy level this molecule also shows reduced transport. 

The permeabilities of the acid examples rise with increasing phospholipid content, up to 20% lipid, with rank ordering preserved (data not shown). Naproxen and ketoprofen show the most dramatic increases in going from 2% to 10% lipid membranes - somewhat higher in soy than in egg. Piroxicam shows less 

The nonionizable molecules respond to the changes in the phospholipid content, with griseofulvin having the highest permeability in the lowest phospholipid-containing membranes. 

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