Peritonitis, acute faecal

Figure 5.5 Plasma id-keto-PCFi at 1 h and 4h following acute faecal peritonitis from aortic and designated venous organ sources. Portal venous levels n = 7) were increased (p < 0.05) vs aortic levels (n = 6) at both time periods. Renal venous levels (n = 5) were increased vs. aortic levels at 4h.

Similar studies have been conducted in rats subjected to acute faecal peritonitis. At 1 h and 4 h following the onset of sepsis, portal venous i6-keto-PGFi3 values were increased approximately two fold compared with aortic levels (Figure 5.5). Portal venous iTxB2 concentrations were also increased but not to the extent observed in venous ib-keto-PGFjgj (Figure 5.6). These studies have identified the hepatosplanchnic circulation as a region... 

Figure 5.9 Effect of glucan on survival time in rats subjected to acute faecal peritonitis (LDjoo)- Glucan (40 mg kg i.p., for 5 days prior) decreased survival time p < 0.001) compared with shock controls. Indomethacin (Indo), 10 mg kg ip. 30 min before peritonitis improved survival time p < 0.001) compared with glucan-treated and shock control groups. From Wise et al, with permission...

PGI2. As indicated earlier, id-keto-PGFjgj levels are markedly increased in acute faecal peritonitis in the raP". PGI2 has strong vasodilating actions on... 

EFAD rats also exhibit prolonged survival time to acute intra-abdominal sepsis compared with normal rats Additionally, conjoint therapy with the aminoglycoside antibiotic, gentamicin, of EFAD rats following faecal peritonitis resulted in an improvement in overall survival at 48 h that was not seen with the antibiotic or EFA-deficiency alone. These observations and the beneficial actions of cyclo-oxygenase inhibitors suggest a deleterious effect of these arachidonic acid metabolites in endotoxaemia and sepsis. 

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