Perireceptor events

Carr W. E., Gleeson R. A. and Trapido-Rosenthal H. G. (1990) The role of perireceptor events in chemosensory processes. Trends Neurosci. 13, 212-215. 

Pelosi P. (2001) The role of perireceptor events in vertebrate olfaction. Cell Mol. Life Sci. 58, 503-509. 

Figure 15.8 Schematic representation of the proposed mechanisms for mode of action of OBPs in the perireceptor events. Pheromone (or other semiochemicals) enters the sensillar lymph through cuticular openings (pore tubules), is solubilized by an odorant-binding protein, transported to the olfactory receptors, and protected from degrading enzymes. Interaction with negatively charged sites at the surface of the dendrites triggers a conformational change that leads to the formation of a C-terminal a-helix. The insertion of this helix into the binding cavity ejects the pheromone to the olfactory receptors.

In parallel to the binding assay, we have performed other molecular studies including in situ hybridizations. We will now discuss the possible roles of the MbraOBPs in the treatment of pheromonal blend at the perireceptor events level, supported by data from different experimental approaches. 

This chapter describes some of the principles and mechanisms underlying the primary processes of olfactory signaling, the chemo-electrical signal transduction. We will focus on molecular events that follow the interaction of odorants with olfactory sensory neurons, and leave aside perireceptor events including odorant... 

Perireceptor events and role of lipophilic ligand-carrier proteins... 

Originally, OBPs were discovered in Lepidoptera antennae and considered to be involved in perireceptor events around odorant receptor membranes, while CSPs were found not only... 

At present, it is considerably easier to study pheromone-protein interactions with a variety of smaller-sized soluble binding proteins. A number of such proteins may participate in the so-called perireceptor events [267] to transport pheromones, assist receptors, deactivate the reception site, etc. 

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