Peripheral chronic demyelinating

Chronic toxicity of AChE inhibitors peripheral nerve demyelination with both muscle weak- ness and sensory loss... 

Peripheral neuropathy is degeneration of peripheral nerves. Because motor and sensory axons tun in the same nerves, usually both motor and sensory functions are affected in this disease. Neuropathies may be either acute (e.g., Charcot-Marie-Tooth disease) or chronic (e.g., Guillain-Barre syndrome) and are categorized as demyelinating or axonal. 

Raine, C. S., Wisniewski, H. and Prineas, J. An ultrastruc-tural study of experimental demyelination and remyelin-ation. II. Chronic experimental allergic encephalomyelitis in the peripheral nervous system. Lab. Invest. 21 316-327, 1969. 

A 36-year-old man developed peripheral polyneuropathy after chronic perianal use of an ammoniated mercury ointment. He had very high blood and urine mercury concentrations. Sural nerve biopsy showed mixed axonal degeneration/demyelination. His symptoms improved progressively over 2 years after withdrawal of the ointment, but neurophysiological recovery was incomplete. 

Peripheral neuropathies, autoimmune. Acute or chronic inflammatory neuropathies leading to demyelination and axonal damage of nerves and nerve roots associated with high-titred autoantibodies against gangliosides (e.g. Guillain-Barre syndrome, Miller-Fisher syndrome, acute sensory ataxic neuropathy). 

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