Peripheral binding site

FIGURE 18.39 (a) Interaction of (—)-bis(10)-hupyridone (left side) and (-)-bis(12)-hupyridone (right side) with AChE. The two tryptophane residues of the active and peripheral binding sites are colored magenta. Hydrogen bonds between the inhibitor and the residues of the enzyme are shown as green line. 

A wide variety of vertebrate species have been shown to possess CNS benzodiazepine binding sites and a peripheral benzodiazepine binding site has been described (J O). The vertebrate neuronal benzodiazepine receptors are thought to be intimately associated with GABA receptors, whereas the peripheral binding sites, initially discovered in kidney and... 

Try increasing expression by cells Use more than one targeting molecule Use nonmodulating receptors Use univalent antibodies Block peripheral binding sites Increase dose of targeting agent... 

Kousba, A. A., Sultatos, L. G.. Poet, T. S., and Timctuilk, C. (2004). ComparLson of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics Potential role of a peripheral binding site. Toxicol Sci. 80,239-248,... 

Munoz, F, J, Aldunate, R, and Fnestrosa, N. C, (1999). Peripheral binding site is involved in the neurotrophic activity of acetylcholinesterase. Neutoreixirt 10, 3621-3625. 

T. S. Poet, C. Timchalk, Comparison of Chlorpyrifos-Oxon and Paraoxon Acetylcholinesterase Inhibition Dynamics Potential Role of a Peripheral Binding Site, Toxicd. Sci., 2004, 80, 239-248. 

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