Periodontal disease neutrophils

The use of antibacterial prophylaxis remains controversial owing to a lack of consistent efficacy, potential for development of resistant bacteria, high cost, and lack of impact on patient survival. Therefore, antibacterial prophylaxis is not recommended routinely for all neutropenic patients. Prophylaxis (with trimethoprim-sulfamethoxazole or quinolone-penicillin) generally is indicated for patients expected to be profoundly neutropenic for more than 1 week, such as HSCT patients. Additional risk factors that may provide justification for prophylaxis include mucous membrane or skin lesions, presence of indwelling catheters, need for instrumentation, severe periodontal disease, or other risk factors. Neutrophil recovery eliminates the need for continued prophylaxis, and recovery may be facilitated by use of... 

Pouhot, M and Serhan, CN (1999) Lipoxin A4 and aspirin-triggered 15-epi-LXA4 inhibit tumor necrosis factor-alpha-initiated neutrophil responses and trafficking novel regulators of a cytokine-chemokme axis relevant to periodontal diseases. J Periodontal Res, 34, 370-373. 

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