Per-modification at the C6-Position

Treating the hepta-iodo-) -CyD derivative with NaNs in DMF gave, in 96% yield, the hepta-azide, which was methylated using a large excess of Mel and NaH to afford the permethylated derivative quantitatively. Treatment with PhsP followed by aqueous NH3 furnished the hepta-amino-/ -CyD. The disaccharide ontaining ligand was coupled, affording the persubstituted product (79%) [60]. 

Amphiphilic heptakis(6-alkylthio)- 8-CyD derivatives were synthesized and their monolayer behavior on a water surface was studied on the basis of surface-molecular area [n-K) isotherms [61]. j8-CyD functionalized at the 6-position with trifluoromethylthio groups have been obtained from the native j8-CyD [62]. Heptakis(2,3-dihexanoyl)-yS-CyD, heptakis(6-hexanamido)-j8-CyD, and heptalds(6-myristamido)-j8-CyD have been synthesized and nanocapsules prepared by nanoprecipitation [63]. Heptakis(6-0-amphiphilic)-jS-CyDs with substituents of varying chain lengths (C and C14) and bond types (ester or amide) have been studied [64]. 

A novel chiral stationary phase was prepared by immobilization of heptakis(6-azido-6-deoxy-2,3-di-0-phenylcarbamoylated)-jS-CyD onto the surface of amino-functionalized silica gel via multiple urea linkages [65]. 

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