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Peptoid Inhibitors of RNA-Protein Interactions

Peptoid hbraries have also yielded compounds active in the disruption of RNA-protein interactions. Compounds not derived from library syntheses are discussed in Section 1.4.1. A peptoid 9-mer with a number of cationic groups was discovered (Fig. 1.4) after several rounds of mixture deconvolution, that was able to block the interaction of HIV-1 Tat protein with TAR RNA at nanomolar concentra- [Pg.6]

IC5Q — 3.4 pM gastrin-releasing peptide/bombesin receptor [Pg.7]

Peptoid-Based Drug Delivery and Molecular Transporters Cellular Uptake [Pg.8]


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