Peptidyl amino acid hydrolase

See Section IV.1 for alternative methods of chiral resolution. Partial chemical hydrolysis of proteins and peptides with hot 6 M HC1, followed by enzymatic hydrolysis with pronase, leucine aminopeptidase and peptidyl D-amino acid hydrolase, avoids racemiza-tion of the amino acids281. The problems arising from optical rotation measurements of chiral purity were reviewed. Important considerations are the nonideal dependence of optical rotation on concentration and the effect of chiral impurities282. [Pg.1089]

These enzymes require a metal for activity and are inhibited by metal-chelating compounds. They are exopeptidases and include carboxypeptidase A (peptidyl-L-amino-acid hydrolase) and B (peptidyl-L-lysine hydro-... [Pg.304]

Carboxypeptidase A Carboxypeptidase Peptidyl-L-amino-acid hydrolase 3.4.12.2 Small intestine Peptides... [Pg.158]

Peptidyl-L-amino-acid hydrolase Peptidyl-L-lysine (L-arginine) hydrolase... [Pg.481]

This enzyme [EC 3.1.1.29], also called peptidyl-tRNA hydrolase, catalyzes the hydrolysis of an A-substituted aminoacyl-tRNA to produce an A-substituted amino acid and tRNA. [Pg.53]

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