Peptidomimetics for SH2 domains

CHAPTER 17 Conformational Restriction and/or Steric Hindrance in Medicinal Chemistry 

FIGURE 17.14 Compound 2, obtained by metathesis, is an excellent mimic of 1. 

FIGURE 17.15 A pseudo peptide is obtained if a cyclopropyl unit is embedded in a peptide, the amide bound is lost but the side chains maintain the spatial disposition of the side chain as in the native peptide. 

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