Peptidoglycan antibiotics affecting synthesis

P-Lactam antibiotics show their lethal effect by inhibiting the synthesis of bacterial peptidoglycan, thereby disrupting the cell morphology and eventually resulting in cell lysis and death. Because the antibacterial effect of P-lactam is affected by the permeability of the outer membrane of bacteria, it is important in the evaluation of drug efficiency... 

A) Oral bioavailability is affected by first-pass hepatic metabolism Only third-generation cephalosporins cross the blood-brain barrier Procaine penicillin G is the most commonly used intravenous form of the antibiotic Renal tubular reabsorption of beta-lactams is inhibited by probenecid Nafcillin and ceftriaxone are eliminated mainly via biliary secretion The mechanism of antibacterial action of cephalosporins involves (A) Inhibition of the synthesis of precursors of peptidoglycans Interference with the synthesis of ergosterol Inhibition of transpeptidation reactions Inhibition of beta-lactamases Binding to cytoplasmic receptor proteins... 

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