Peptidic metabolite

Several other, more complex cysteine-derived polychlorinated peptide metabolites are known to arise in marine organisms. Dolabellin (968) was characterized from the Japanese sea hare Dolabella auricularia 1004). The absolute... 

A strong influence on the biosynthesis of peptide metabolites exerted by exogenously supplied amino-acid precursors has been observed earlier both in prokaryotes and eukaryotes [26]. In several cases, enhanced yields of a desired metabolite can be obtained and a replacement of certain constitutional building elements by other amino acids may occur [27, 28]. 

Ruegger, A., Kuhn, M., Lichti, H., Loosli, H., Huguenin, R. et al. (1976). Cyclosporin-A, a peptide metabolite from Trichoderma polysporum rifai, with a remarkable immunosuppressive activity. Helv. Chim. Acta 59, 1075-1092. 

The Hawaiian sacoglossan Elysia rufescens sequesters the depsipeptide metabolite kahalalide F 184 from its algal diet Bryopsis sp. Both algal and mollusk extracts were deterrent when tested against natural populations of reef fish, as was the peptide metabolite.208 Kahalalide F shows potent cytotoxicity against a range of tumor cell lines.209... 

TMC-95A, a cydic peptide metabolite from Apiospra montagnei, is a potent competitive inhibitor of all active sites and forms characteristic hydrogen bonds with the protein backbone. The crystal structure of the yeast 20S proteasome in complex with TMC-95A indicates a non-covalent linkage to the active y -subunits the N-terminal threonine residues are not modified. The TMC-95A backbone adopts a -conformation and extends the -strand SI by the generation of an antiparallel P-sheet. This stmcture is similar to that seen with the aldehyde and epoxyketone inhibitors. An interactions of TMC-95A are formed with main-chain atoms and strictly conserved residues of the 20S proteasome. 

Cyanobactins - Ubiquitous Cyanobacterial Ribosomal Peptide Metabolites... 

Ruegger A, Kuhn K, Lichti H, Loosli HR, Huguenin R, Quiquerez C, von Wartburg A. Cyclosporin A a peptide metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity. Helv Chim Acta 59(4) 1075-1092, 1976. 

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