Selectin peptidic antagonists

Otvos, L., Jr., Kieber-Emmons, T., and Blaszczyk-Thurin, M. (2002) Role of SA-Lea and E-selectin in metastasis assessed with peptide antagonist. Peptides 23, 999-1010. 

In summary, peptide fragments of the three selectins display very interesting biological activities in vitro as well as in vivo. However, their translation into peptidomimetics, a necessity due to the inadequate plasma stability of peptidic antagonists, has not yet been reported. 

Molenaar, T J M, Appeldoom, C C M, de Haas, SAM, Michon, I N M, Bonnefoy, A, Hoylaerts, M F, Pannekoek, H, van Berkel, T J C, Kuiper, J, Biessen, E A L, Specific inhibition of P-selectin-mediated cell adhesion by phage display-derived peptide antagonists. Blood, 100, 3570-3577, 2002. 

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