Peptides imprinted chiral phases

Stationary phases with specific molecular recognition properties for D,L-enantiomers of peptides have been tailored using the molecular imprinting technique. A template molecule is added to suitable monomer(s), the system is polymerized, and the chiral template molecule is washed out [128]. 

The high selectivity of M IPs is demonstrated when an optically active compound is imprinted the resulting MIP will normally resolve the racemate. Numerous reports on MIP chiral stationary phases have appeared [184—188]. Chiral templates studied include amino acids [26, 29, 120, 139, 189-192], peptides [139, 192, 193], carbohydrates [58, 194, 195] and dmgs [127, 196]. 

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