Peptides and Proteins Encapsulated in Chitosan

3 Peptides and Proteins Encapsulated in Chitosan 14.6.3.1 Bovine Serum Albumin (BSA) 

Bovine serum albumin is the most common protein used as a model protein. In general, researchers first carry out the in-vitro assays with this protein [98]. It has been reported that microencapsulated beads composed of alginate blended with a water-soluble chitosan have been evaluated for delivery of BSA [110]. 

Inhalable co-spray dried powders of salmon calcitonin-loaded chitosan nanoparticles with mannitol have been prepared and analyzed. Salmon calcitonin or Calcitonin (also known as thyrocalcitonin) is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimobranchial body. It acts to reduce blood calcium (Ca ), opposing the effects of parathyroid hormone (PTH) [118]. The 

The FDA approved chitosan only in the management of minor topical bleeding wounds such as minor abrasions and minor skin lacerations (http //www.fda.gov/default.htm). Chitosan is not approved by the FDA for any product in drug delivery, and as a consequence very few biotech companies are using this material [120]. 

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