Peptide glycopeptide antibiotics

Macrocyclic peptides as antibacterial glycopeptide antibiotics 98KGS1605. 

One of the most characteristic features of FRET is its sensitive dependency on the fluorophore distance. This is advantageously used to evaluate structures and conformational changes of peptides, glycopeptides, and proteins among other molecules [164-166], The conformational change of the lipopeptide antibiotic daptomycin from an inactive linear form to a biological active cyclic form... 

It is now well understood that all glycopeptide antibiotics exert antibiotic activity against Gram-positive bacteria because they stereospecifically bind to the precursor peptidoglycan peptide terminus A-acyl-o-alanyl-D-alanine produced during bacterial... 

The glycopeptide antibiotics such as vancomycin and chloroeremomycin are complex nonribosomal peptides. One of the nonprotein amino acids found in these antibiotics is 4-hydroxyphenylglycine. The biosynthetic pathway of this nonprotein amino acid has been studied and prephenate was... 

A47934 - peptide antibiotic (glycopeptide antibiotics, vancomycin and chioroeremomycin, also contain this amino acid)... 

The majority of these are antibiotics and they cover a diverse group including the glycopeptide, avoparcin (95), tetracycline, macrolides, such as tylosin (23) and virginiamycin (96), as well as peptides, glycopeptides and terpenes. Antibacterials such as the quinoxaline-1,4-dioxide, carbadox (39), and nitrofurans, e.g. furazolidone (35) and nitrovin (97), are also represented. 

Scheme 2-4. (a) Binding of vancomycin to the Lys-D-Ala-D-Ala peptide motive with Hve hydrogen bonds, (b) Dimerization of vancomycin-type glycopeptide antibiotics (e.g., chloroeremomycin) over six hydrogen bonds. Because vancomycin lacks a vancosamine sugar at AA6, it interacts only over four hydrogen bonds. 

The glycopeptide antibiotics are glycosylated secondary metabolites of bacteria and fungi that are s)mthesized by non-ribosomal peptide synthetases. The term glycopeptide antibiot-... 

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