Peptide-Based Receptors

In recent years anion receptors based on peptides (oligomers of amino acids) have become of increasing interest, not least because of their resemblance to biological receptors. The archetypal example is the antibiotic vancomycin illustrated in Section 1.5. Vancomycin binds to the L-Lys-D-Ala-o-Ala 

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Due to the clinical availability of Octreoscan , the first peptide-based receptor-imaging radiopharmaceutical, there has been much interest in the development of a complimentary therapeutic radiopharmaceutical.89... 

Figure 11.23 A resin-bound peptide-based receptor used as part of an IDA-based pattern sensor with fluorescein.33...

Peptide-based receptors can be distinguished according to the type of snbstrate recognized (cationic, anionic, and... 

This chapter does not cover the use of metal ions as allosteric effectors (3), skeletal components (4) (see Crystal Engineering, Supramolecular Materials Chemistry), or sensing elements (5) (see Molecular Redox Sensors, Colorimetric Sensors and Luminescent Sensing, Supramolecular Devices). It also does not address the interaction of metal complexes with biological systems (see Synthetic Peptide-Based Receptors, Biological Small Molecules as Receptors, Molecular Recognition and Supramolecular Bioinorganic Chemistry, Supramolecular Aspects... 

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