Peptic ulcer disease definition

Finally, it is universally accepted at present that Helicobacter pylori infection has a definitive ethiological role in peptic ulcer disease, and that erradication therapy is warranted in these clinical scenarios. The majority of therapeutic trials have included the application of triple therapy with proton pump inhibitors or ranitidine bismuth citrate, clarithromycin and either amoxycillin or metronidazol and is to date the treatment of choice. However, recent studies have reported antibiotic resistance which can be one reason for failure of treatment of Helicobacter pylori infection [101-103], and new treatment strategies are therefore Wellcome. Flavonoids, in addition to their gastroprotective activity previously commented, have been also shown to inhibit Helicobacter pylori growth in vitro. In this way, Beil et al. [50]... 

Observational cohort or case control designs have been used to determine ADR relationships with specific therapeutic classes. " Medical claims data are often used in these studies and caution should be warranted due to lack of definite confirmation of drug exposure and the potential for confounding variables. However, these studies have been beneficial in determining risk of ADRs with specific classes (e.g., NSAIDs and the risk of peptic ulcer disease). 

The establishment of the role of add in the genesis of peptic ulceration was supported by studies undertaken jointly by I. N. Marks (left) and W. Card (right) of Cape Town and Edinburgh, respectively, who concluded that acid secretion was a function of parietal cell mass. They established that histamine stimulation could be used to assess the function of the parietal cell mass. This work facilitated the recognition that acid output, parietal cell mass, and peptic ulceration were inextricably linked. As a result of these physiopathologic observations, a rational basis was provided for the consideration of add reduction-initially surgically and subsequently by pharmacotherapeutic means-as a definitive intervention in the management of add peptic disease. 

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