Soft tissue sarcoma pentachlorophenol

Case reports and case control studies in humans have suggested a possible association between cancer, including soft tissue sarcoma, acute leukemia, Hodgkin disease, and non-Hodgkin lymphoma, and occupational exposure to pentachlorophenol. However, in all cases concomitant exposure to other toxic substances may have contributed to the effects seen. "... 

Associations with chlorophenols were, however, analysed in two case-control studies nested within 24 of the 36 cohorts of the lARC study. These compared 11 cases of soft-tissue sarcoma and 32 cases of non-Hodgkin lymphoma with 55 and 158 controls, respectively (Kogevinas et al., 1995). Exposure to chlorophenols, phenoxy acid herbicides, dibenzodioxins and -furans and other agents was assessed by a team of industrial hygienists (Kauppinen et al., 1994). Odds ratios for non-Hodgkin lymphoma, not adjusted for exposure to other agents, were 1.3 (95% CI, 0.5-3.1) for any chlorophenol, 2.8 (0.5-17.0) for pentachlorophenol and 1.0 (0.3-3.1) for 2,4-dichlorophenol. No excess risk was found in relation to other chlorophenols, but the munber of exposed cases was small. The odds... 

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