Penicillium isochromophilones

Isochromophilones VII (190) and VIII (191) from a Penicillium sp. inhibit diacylglycerol acytransferase activity with IC5o values of 20.0 and 127 pM and acyl-CoA cholesterol acyltransferase activity with IC50 values of 24.5 and 47.0, respectively. They also show moderate antimicrobial activity [153]. 

Matsuzaki K, Ikeda H, Masuma R, Tanaka H, Omura S (1995) Isochromophilones I and II, Novel Inhibitors against gpl20-CD4 Binding Produced by Penicillium multicolor FO-2338 I. Screening, Taxonomy, Ferrmentation, Isolation and Biological Activity. J Antibiot 48 703... 

Arai N, Shiomi K, Tomoda H, Tabata N, Yang DJ, Masuma R, Kawakubo T, Omura S (1995) Isochromophilones III VI, Inhibitors of Acyl-CoA Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216. J Antibiot 48 696... 

Michael AP, Grace EJ, Kotiw M, Barrow RA (2003) Isochromophilone IX, a Novel GABA-Containing Metabolite Isolated from a Cultured Fungus, Penicillium sp. Aust J Chem 56 13... 

Isochromophilones I (14, 15), the new gp 120-CD4 binding inhibitors, were isolated from a culture broth of Penicillium multicolor FO-2338 grown on a medium with carbon and nitrogen sources. Their amounts in the medium were 2 mg/1 and their chemical structures were elucidated... 

New azaphilones named isochromophilones III-VI (18-21) were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of ACAT. Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones (17-20) (ACAT) activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 pM, respectively [79]. 

Isochromophilone IX (24), a novel GABA-containing metabolite, was isolated from a cultured fungus, Penicillium sp. [81]. 

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