Penicillin concentration fermentation time

Penicillin V Bioreactor Train Three cases maximization of (a) both penicillin yield and concentration at the end of fermentation, (b) penicillin yield and batch cycle time, and (c) penicillin yield and concentration at the end of fermentation as well as profit. NSGA-II Glucose feed concentration is the decision variable contributing to the Pareto-optimal front. Multiple solution sets producing the same Pareto-optimal front were observed. Lee et al (2007)... 

For the extraction and subsequent derivatization of penicillin G from a fermentation broth, Scheper et al. (48) utilized an ELM system containing the enzyme pencillin acylase in the internal phase to convert the extracted penicillin G to the products 6-aminopenicillinic acid and phenylacetic acid. Recently, Lee and Lee (49) and Mok et al. (50) successfully performed the ELM extraction of this penicillin with sodium carbonate in the internal phase. Mok et al. (50) gave an ELM system for this extraction, which is shown in Table X. They obtained extraction eflBciencies between 80% and 95% for emulsion/feed ratios ranging from 0.167 to 0.2 and an internal phase concentration of greater than 9 times the initial concentration in the external feed phase. In addition, extraction of peptides was investigated recently (51). 

The maximum principle has been applied to the above model to determine the optimal temperature profile (see Ref. [7]), which maximizes the concentration of penicillin at the final time of the fermentation, tf-. The maximum principle algorithm when applied to the state equations, (1) and (2), yields the following additional equations ... 

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