Penicillamine protein conjugate

Laycock, C. A, Phelan M. J. I Bucknall, R. C., and Coleman J W. (1994) A western blot approach to detection of human plasma protein conjugates derived from D-penicillamine. Ann Rheum Dis 53, 256-260... 

Experimentally, the capacity of the D-penicillamine group to act as antigenic determinant has been shown by Assem and Vickers (1974), immunizing rabbits with penicillamine-disulfide protein conjugates. The immunogenicity of D-penicillamine itself, as used for treatment of Wilson s disease or in rheumatic disorders, has been demonstrated (Amos 1973), It has also been shown that penicillamine can behave as experimental contact sensitizer in guinea pigs (Levine 1960 a Caron 1963). 

Coleman JW, Foster AL, Yeung JH, Park BK. Drug-protein conjugates—XV. A study of the disposition of o-penicillamine in the rat and its relationship to immunogeni-city. Biochem Pharmacol 1988 37(4) 737-742. 

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