Penicillamine Cimetidine

The most frequent offenders are cytostatic agents and anticoagulants, but hair loss can occur with a variety of common drugs, including hormones, anticonvulsants, amantadine, amiodarone, captopril, cholesterol-lowering drugs, cimetidine, colchicine, etretinate, isotretinoin, ketoconazole, heavy metals, lithium, penicillamine, valproic acid, and propranolol. 

There are 12 other cases of maeromastia and gynaecomastia on record associated with the use of penicillamine, in some of which the second trigger may possibly have been a corticosteroid or cimetidine. Maeromastia appears to be an unusual adverse effect of penicillamine and there would seem to be no general reason for patients taking penicillamine to avoid oral contraceptives. 

Harpey JP, Caille B, Moulias R, Goust JM (1972) Drug allergy and lupus-like syndrome (with special reference to d-penicillamine). In Dash CH, Jones HEH (eds) Mechanisms in drug allergy. Churchill Livingstone, Edinburgh London, pp 51-57 Idvall J (1979) Cimetidine-associated thrombocytopenia. Lancet 2 159... 

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