Peganum harmala alkaloids

N. D. 2000. Alkaloids of Peganum harmala. Chemistry of Natural Compounds, 36(6) 602-605. 

Ross, S. A., Megalla, S. E., Bishay, D. W. and Awad, A. H. 1980. Studies for determining antibiotic substances in some Egyptian plants. Part II. Antimicrobial alkaloids from seeds of Peganum harmala. L. Fitoterapia, 6 309-312. 

Zayed, R. and Wink, M. 2005. Beta-carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala. Zeitschrift fur Naturforschung C-A Journal of Biosciences, 60(5-6) 451 58. 

Material Indole-based alkaloid found in several places including Banisteriopsis caapi (from which the South American hallucinogenic brew yage is prepared), Peganum harmala (Syrian rue), Zygophyllum fabago and Passiflora incarnata. ... 

The condensation of a heterocyclic enamine with o-aminobenz-aldehyde, leading to the alkaloids of Peganum harmala, desoxy-vasicine371 and vasicine,372 also include aldol-type reactions. The... 

There is a little bit of interesting history connected with the melting point of harmaline. A report appeared that described an alkaloid from Peganum harmala... 

But do remember, with the harmaline and harmine content of the seeds of Peganum harmala, you are also accepting an equal weight of quinazoline alkaloids with pharmacological properties that are quite different from those of the carbolines. 

The so-called harmala alkaloids, which are derivatives of carboline, were first found in Peganum harmala, and it was in a study of these that the nuclear structure in which an indole nucleus is fused with a pyridine nucleus was first recognized. Many of the polynuclear indole alkaloids contain the carboline (harman) nucleus, but it is often concealed in such a manner that it may be difficult to recognize. The following discussion will be limited to the derivatives of carboline in which no further nuclei occur. 

The numbering of the carboline ring system (I) adopted here is that of the Ring Index. It differs from some of the systems in use, but, since there has been considerable diversity and some confusion, it is hoped that the present system will be generally adopted. This chapter is a summary and extension of that dealing with the alkaloids of Peganum harmala, Volume II, p. 393. 

An alkaloid obtained from peganum, the dried seeds of Peganum harmala (Zygophyllaceae). It is also found, together with harmine, in the South American hallucinogenic drink caapi , also known as Yage and ayahuasca . 

In 1888, Hooper first investigated the pharmacological action of an extract of Adhatoda vasica Nees containing compound 184. In 1925, Ghose and Sen isolated this component and named it vasicine. In 1934, Spath and Nikawitz isolated an alkaloid from Peganum harmala and named it pe-ganine, but soon afterward Sp th and Kuffner showed it to be identical with vasicine. This alkaloid (184) was found not only in Adhatoda... 

Since Peganum harmala seeds provide an easily extracted concentrate of harmala alkaloids, and since this extract, combined with orally ingested DMT or psilocybin evokes an extremely potent psychedelic experience, the following formula is offered. Of all of my various experiments in this field, this one has been the most rewarding. It is so simple that anyone can perform it successfully without specialized equipment. (It doesn t even require de-fatting or extraction with an organic solvent ) Indeed, if one were to forget every other plant in this... 

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