PEG-doxorubicin

Veronese FM, Schiavon O, Pasut G, Mendichi R, Andersson L, Tsirk A, Ford J, Wu G, Kneller S, Davies J, Duncan R (2005) PEG-doxorubicin conjugates influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity. Bioconjug Chem 16 775-784... 

Zhu and Zhao prepared pH-sensitive polymeric vesicular aggregates using combshaped amphiphilic polymers, i.e., cholate grafted poly(L-lysine) (PLL-CA), with an amphiphilic PEG-doxorubicin (DOX) conjugate (Figure 2.11) [57c]. The pH sensitivity leads to better uptake of the vesicles by cancer cells (MCF-7) under conditions close to the extracellular environment of a solid tumour (pH = 6.5) and subsequent escape from endosomes after endocytosis. Moreover, if the pH value is lower the vesicles destabilise. 

Amphiphilic block copolymer micelles PLGA-PEG Doxorubicin Treatment of hepatocellular carcinoma [115]... 

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See also in sourсe #XX -- [ ]

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