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Pediatrics pharmacometrics

COVARIATE IMPACT IN PEDIATRIC PHARMACOMETRICS 39.5.1 Size as a Covariate... [Pg.966]

Toxicology and Applied Pharmacology Obstetrics and Gynecology British Medical Journal Pediatric Research Oyo Vakuri (Pharmacometrics)... [Pg.10]

One of the most potent applications of pharmacometrics is the informative construction of clinical trials by using clinical trial simulation (CTS). Population PM models are of great value when used in CTS because estimates of typical parameters along with parameter variability can be incorporated. There are three basic types of models needed to execute a CTS an input-output model, a covariate model, and an execution model. These are described in detail in Chapter 34 of this book. Clinical trial simulation can improve pediatric study structure by examining the impact of many important factors such as dropouts, choosing varying endpoints, and deviations from protocol. Pediatric PM models find great utility when applied to CTS. [Pg.970]

See other pages where Pediatrics pharmacometrics is mentioned: [Pg.958]    [Pg.967]    [Pg.958]    [Pg.967]    [Pg.956]    [Pg.957]    [Pg.961]    [Pg.1222]   


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