Pd-Catalyzed Enantioselective C—H Bond Functionalization Reactions

Despite the recent progress in palladium-catalyzed diastereoselective iodin-ation, acetoxylation, and arylation reactions,Pd-catalyzed enantioselective C—H bond functionalizations are rather challenging due to lack 

In 2012, a comprehensive computational study revealing the key mechanistic features of enantioselective C—H bond activation reactions of pyridine-containing substrates was reported by Musaev, Yu, and co-workers. The mono-N-protected amino acid was confirmed to coordinate to the Pd center in a bidentate fashion. The DFT calculation therein strongly favored 

Chiral spirocyclic indenes and indanes represent a class of important structures frequently found in biologically active natural products. The catalytic asymmetric construction of such compounds bearing quaternary 

Recently, Gong and eo-workers realized enantioseleetive a-allylation of aldehydes with terminal alkenes by employing the strategy of asymmetric counteranion catalysis and Pd-catalyzed allylie C—H bond activation.  

Pd-catalyzed enantioselective C—H bond functionalization featuring a Pd /Pd catalytic cycle was first reported by Wang and co-workers. They employed phenylacetic acid derivatives as model substrates to construct structurally valuable benzofuranones via C—H bond activation. Based on the previous findings that MPAA ligands can facilitate asymmetric C—H bond functionalization reactions, they found Ac-Gly-OH was the optimal ligand. 

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