PCNA A Protein with Many Partners

The growing list of proteins interacting with PCNA includes DNA polymerases TJ, 52 53 54 jgjujinal nucleotidyl transferase, the Werner syndrome helicase, AP 

PCNA paitners, including the CDK inhibitor p21, interact with the interdomain connector loop of PCNA through a motif of 8 aminoacids (QxxM/L/IxxFF/FY). PARP-1 shows a putative PCNA-binding consensus sequence (QDLIKMIF) at the position 669 within the catalytic domain that is essential for the conversion of NAD into ADP-ribose. 

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