Pateamine Mycale

Northcote, P. T., Blunt, J. W., andMunro, M. H. G. (1991). Pateamine A potent cytotoxin from the New Zealand marine sponge, Mycale sp. Tetrahedron Lett. 32, 6411—6414. 

Rzasa, R. M., Shea, H. A., and Romo, D. (1998). Total synthesis of the novel, immunosuppressive agent (-)-Pateamine A from Mycale sp. Employing a b-lactam-based macrocyclization. J. Am. Chem. Soc. 120, 591—592. 

Polyket mixed biogenesis macrolides (pateamine A from Mycale sp., Poecil., Porif from NZ Northcote 1991) macrocyclic ethers y-pyrones (Phaceiocarpus sp., Gigartinales, Rhodoph. from SE Australia and Tasmania Murray 1995). 

Pateamine (606), a potent cytotoxin containing a dilactone functionality, was isolated from a New Zealand species of Mycale and identified by analysis of spectral data [480]. Total synthesis of pateamine A (606) involved a (3-lactam based macrocyclisation [481,482], while another total synthesis of pateamine employed a concise and convergent route [483]. 

Pateamine (39) is a macrolide isolated from a marine sponge Mycale sp. Its potent cytotoxicity is attribnted to inhibition of transcriptional initiation (19). 

Pateamine (49), a thiazole-containing macrolide with a 19-membered dilactone functionality, was isolated from the New Zealand marine sponge Mycale sp., collected on the southwest coast of the South Island of New Zealand. Pateamine (49) had potent in vitro antifungal (MIC values Candida albicans, 1 pg/ml Trichophyton mentagrophytes, 20 ng/ml Cladosporium resinae, 0.4 pg/ml) and cytotoxic... 

Northcote PT, Blunt JW, Munro MHG. Pateamine a potent cytotoxin from the New Zeland Marine sponge, mycale sp. Tetrahedron Lett. 1991 32(44) 6411-6414. 

Remuinan, M.J. and Pattenden, G. (2000) Total synthesis of (—)-pateamine, a novel polyene bis-macroHde with immunosuppressive activity from the sponge Mycale sp. Tetrahedron Lett., 41, 7367-7371. 

Pattenden, G., Critcher, D.J., and Remuinan, M. (2004) Total synthesis of (—)-pateamine A, a novel immunosuppressive agent Irom Mycale sp. Can.]. Chem., 82, 353-365. 

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