Pateamine derivatives

Synthesis of Derivatives of Pateamine A and Structure Activity Relationship Studies... 

Table 14.1 IL-2 reporter gene assay (transfected Jurkat T cells) activity of pateamine A and derivatives... 

Romo, D., Choi, N.S., li, S., Budiler, 1., Shi, Z., and Liu, ).0. (2004) Evidence for separate binding and scaffolding domains in the immunosuppressive and antitumor marine natural product, pateamine A design, synthesis, and activity studies leading to a potent simplified derivative./.Am. Chem. Soc., 126,10582-10586. 

Intramolecular alkenyl-alkenyl Stille cyclization was used in the synthesis of macrocydes such as Bafilomycin A [115], ( )-isocembrene [116], Lankaddins [117], Sanglifehrin [118], (-i-)-Concanamydn F [119], (-)-Pateamin [120], Apoptoli-din [121], Concanamycin F [122], (-)-Lasonolide A [123], Rhizoxin D [124], Amphi-dinolide A [125], and thiazole derivatives related to Leinamycin [126] (Scheme 6.15). 

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