Past Confusion in Assessment of HPPs

Confusion between Water Soiubie Salts of Inoi anic Metals and Related but Insoluble 

Confusion Between Pigments and their Associated Impurities 

False Positives in Cenotoxicity Testing of Organic HPPs 

The use of dimethyl sulfoxide (DMSO) as an aid to mutagenic testing of organic HPPs is to be deprecated. This technique is commonly used to render the substance being tested at least partially soluble and thus more bioavailable. In the case of organic pigments, however, any solubilization which may take place essentially transforms the pigment into a bioavailable dyestuff, rather than an inert, unreactive, and nonbioavailable substance, and can produce false positive test results. 

Over-Reliance on Structure Activity Relationship (SAR) Assessment of HPPs 

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