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Partition coefficient, of drug

P Partition coefficient (of drug) between normal octanol and water... [Pg.3]

JJ Ramsden. Partition coefficients of drugs in bilayer lipid membranes. Ex-perientia 49 688-692, 1993. [Pg.183]

Poulin, P. and Theil, E.P. (2000) A priori prediction of tissue plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. Journal of Pharmaceutical Sciences, 89, 16-35. [Pg.239]

The partition coefficients of triphenylalkylphosphonium homologs have been determined in gel bead-immobilized small or large unilamellar liposomes by chromatography [8]. It was claimed that the technique, immobilized liposome chromatography (ILC), is suitable for the determination of membrane partition coefficients of drugs. [Pg.53]

V, steady-state volume of distribution referenced to the unbound drug in plasma. Kp, partition coefficient of drug between plasma protein and plasma water, r, ratio of the fractions of the drug non renally and renally eliminated. [Pg.54]

Wang PH, Lien EJ. Effects of different buffer species on partition coefficients of drugs used in quantitative structure-activity relationships. J Pharm Sci 1980 69 662-8. [Pg.270]

Table 17.3 Partition coefficients of drugs between octanol and water. (See Table 15.1 for coefficients of hypnotics and general anaesthetics which average logP = 2.0)... Table 17.3 Partition coefficients of drugs between octanol and water. (See Table 15.1 for coefficients of hypnotics and general anaesthetics which average logP = 2.0)...
Poulin P, Haddad S. 2013. Hepatocyte composition-based model as a mechanistic tool for predicting the cell medium partition coefficients of drugs in incubation mediums. J Pharm Sci 102 2806-2818. [Pg.80]

The effect of tri-0-methyl-3-cyclodextrin( methyl-3-CD ) on the partition coefficients of drugs, such as p-nitrophenol, salicylic acid, benzoic acid, and aspirin, was studied at 25 °C. The partition... [Pg.523]

In this study, the effect of methyl-B-CD on the partition coefficients of drugs was investigated (M. The interaction between... [Pg.524]

Fig. 1 Effect of Methyl- -CD on Partition Coefficients of Drugs at 25°C Aqueous phase 0.2 N HCl, Organic phase CHCb... Fig. 1 Effect of Methyl- -CD on Partition Coefficients of Drugs at 25°C Aqueous phase 0.2 N HCl, Organic phase CHCb...

See other pages where Partition coefficient, of drug is mentioned: [Pg.138]    [Pg.12]    [Pg.28]    [Pg.41]    [Pg.162]    [Pg.230]    [Pg.157]    [Pg.566]    [Pg.2428]    [Pg.673]    [Pg.123]    [Pg.31]    [Pg.524]    [Pg.525]    [Pg.92]   


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