Partial pressures chlorofluorocarbons

Eight healthy human volunteers, four males and four females, ages 20-24, were exposed individually (whole body) to concentrations at 0 (air), 1,000, 2,000, 4,000, or 8,000 ppm for 1 h in a 13.6 m3 room (Emmen and Hoogendijk 1998 Emmen et al. 2000).2 Each subject was exposed at each concentration in a partially blind ascending order of concentration. With the exception of one 14-d interval, each exposure was separated by a period of 7 d. Chlorofluorocarbon-12 (CFC-12) was used as a reference compound. No mention was made of the ability of the test subjects to recognize the odor of either test chemical. Prior to and during exposures, blood pressure and cardiac rate and rhythm (EKG) were monitored. Pulmonary function, as indi... 

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