Pareira brava

Brodie s Decoction of Pareira Brava. Tako k onneo bruised pareira root, and 3 pints boiling water boil down gently to 1 pint, and filter. Dose, 1 wine-glassful... 

Pareira. Pareira brava. Dried root of Chondoden-dron planphyllum (A. St. Hit.) Miers, C. microphyllum (Eichl.) Mold., and C tomenlosum Ruiz et Pa von, Menisper-maceae. Habit. Brazil. Constit. Bebeerine, chondrodioe, fatty acids, tannin. 

Turpentine. Balfam of Copaiva. Refin. Olibanum. Afparagus, garlic, wild daucus. Parfley, apium. Fennel, feniculum, pareira brava, ciflampelos Externally cold air, cold water. 

In 1843 Maclagen (56) found two compounds of basic nature in Nectan-dra roots from British Guiana. One of these, an amorphous yellow powder, he named bebeerine (bebirine). Some time later a yellow powder was isolated from Buxus sempervirens L., whose fibers and leaves were used as a remedy for intermittant fever. This powder which was named buxin proved to be identical with bebeerine. Finally, the alkaloid known as pelosine which occurs in the roots of Cissampelos pareira L. and Radix pareira bravae was found to be identical with bebeerine (56, 59). Bebeerine also occurs in Chondodendron platyphyllum, Ch. microphyllum, Abula candicans Rich. Ch. candicans Sandwith) (68), and Pleogyne cunninghamii (136), as well as in the commerical powder known as bebeerum purum. 

Chondrodendron microphyllum (Eichler) Mold, and Chondrodendron platU phyllum (A. St.Hil.) Miers, both apparently sources of the formerly much used drug pareira brava (169), have a very restricted occurrence. They are known only from the eastern and southeastern coastal regions of Brazil the... 

Kupchan et al. [170] discuss the origin of the old drug radix pareirae bravae, and in view of the similarity in alkaloid composition of some forms of C. pareira to that of Chondrodendron microphyllum and Chondrodendron platiphyllum (q.v.) they suggest that C. pareira may have been a further source of the drug. However, the particular combination of alkaloids they encountered has not yet been found in material from Brazil. 

---