Propofol Parecoxib

A single perioperative dose of parecoxib did not alter the disposition or the clinical effects of a bolus of propofol (150). 

Ibrahim A, Park S, Feldman J, Karim A, Kharasch ED. Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol. Anesthesiology 2002 96(l) 88-95. 

Limited evidence suggests parecoxib does not affect the pharmacokinetics or clinical effects of propofol. Parecoxib does not appear to interact with nitrous oxide and isoflurane. 

A randomised, placebo-controlled, double-blind, crossover study in 12 healthy subjects found that pretreatment with 40 mg of intravenous parecoxib given one hour before a 2 mg/kg intravenous bolus of propofol did not significantly affect the pharmacokinetics of the propofol. Moreover, parecoxib did not alter the clinical effects of propofol (e.g. the time to loss of consciousness or the speed of awakening). These limited data suggest that no special precautions should be required during concomitant use. 

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